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KMID : 0043320190420090766
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Archives of Pharmacal Research
2019 Volume.42 No. 9 p.766 ~ p.772
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Non-glycosidic iridoids from the roots of Patrinia scabra and their nitric oxide production inhibitory effects
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Lee Da-Hye
Shin Ji-Sun
Lee Jin-Su
Kang Shin-Young
Han Hee-Soo
Ryu Seung-Mok
Lee Kyung-Tae
Lee Dong-Ho
Jang Dae-Sik
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Abstract
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Phytochemical investigation on the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new non-glycosidic iridoids, patriscabrins F?J (1?5), along with a known iridoid 11-ethoxyviburtinal (6). The structures of the new compounds 1?5 were determined by interpretation of spectroscopic data, particularly by 1D- and 2D-NMR and ECD studies. Thereafter, the isolates 1?6 were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, patriscabrin F (1) exhibited the most potent inhibitory effect with observed IC50 value of 14.1 μM. In addition, patriscabrin G (2) and 11-ethoxyviburtinal (6) showed IC50 values 24.6 and 35.5 μM, respectively.
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KEYWORD
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Patrinia scabra, Valerianaceae, Iridoid, Patriscabrin, Nitric oxide
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